Re-Infection Versus Reactivation
Transient infections are cleared by body’s innate immune response; they are less likely result in a memory immune response, which would leave a woman vulnerable to re-infection.
There are cases of reactivation of latent HPV infection which are not necessarily related to a new sexual partner.
Redetection may also be due to autoinoculation or other mucosal _____________ dictation stops here.
The frequency of redetection after documented clearance ranges from 5% – 20%, depending on age, length of followup and the definition of clearance.
Only 3%-5% of patients had redetection of HPV 16 after clearance, defined by at least two consecutive negative tests. After 5 years, 10%-17% had another visit with HPV 16 detected. Sexual behaviors were found to be associated with the redetection of the infections, suggesting that these were infections due to re-exposure.